Research progress of the relationship between pyroptosis and disease

American Journal of Translational Research

Jiaxuan Jiang¹  Tianshu Shi²  Yuan Gao³  Yuze Ma⁴ 

[1] Department of Sports Medicine and Adult Reconstructive Surgery, Drum Tower Hospital, School of Medicine, Nanjing University, Nanjing 210008, P. R. China;Liver Disease Collaborative Research Platform of Medical School of Nanjing University, Nanjing 210093, P. R. China;State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 210009, P. R. China;State Key Laboratory of Pharmaceutical Biotechnology and Jiangsu Key Laboratory of Molecular Medicine and School of Medicine, Nanjing University, Nanjing 210093, Jiangsu Province, P. R. China

关键词: Pyroptosis;    disease;    inflammation;    cell death;   

DOI  :  

学科分类：医学（综合）

来源: e-Century Publishing Corporation

【 摘 要 】

Pyroptosis, characterized by proinflammation, has been defined as a new type of programmed cell death in recent years. Inflammasomes are activated by the corresponding pathogen-associated molecular patterns (PAMPS) or damage-associated molecular patterns (DAMPS), followed up by the cleavage of pro-interleukin-1β (pro-IL-1β), pro-interleukin-18 (pro-IL-18) and gasdermin D. The N-terminal fragment of gasdermin D gives rise to the destruction of cell membrane, leading to cell rupture as well as the efflux of proinflammatory cytokines. Recent studies have shown that pyroptosis is associated with a variety of diseases due to its proinflammation effect and the dysfunction of related cells. The relationship between pyroptosis and associated diseases is described in this review.

【 授权许可】

CC BY-NC