Salivary transforming growth factor alpha in patients with Sjögren's syndrome and reflux laryngitis

Revista Brasileira de Otorrinolaringologia

Eckley, Claudia Alessandra¹  Sardinha, Luiz Roberto²  Corvo, Marco Antonio dos Anjos³  Rizzo, Luis Vicente⁴ 

[1] Hospital Central da Irmandade da Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil;Instituto Israelita de Ensino e Pesquisa Albert Einstein, São Paulo, Brazil;Santa Casa de São Paulo, São Paulo, Brazil;Universidade de São Paulo (USP), São Paulo, Brazil

关键词: Xerostomia;    Laryngopharyngeal reflux;    Sjögren's syndrome;    Saliva;    Epidermal growth factor;    Transforming growth factor alpha.;   

DOI  :  10.1016/j.bjorl.2014.08.006

学科分类：医学（综合）

来源: Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervicofacial

【 摘 要 】

Introduction: Saliva plays a key role in the homeostasis of the digestive tract, through its inorganic components and its protein growth factors. Sjögren's syndrome patients have a higher prevalence of gastroesophageal reflux disease and laryngopharyngeal reflux. Decreased salivary transforming growth factor alpha levels were observed in dyspeptic patients, but there have been no studies in patients with Sjögren's syndrome and laryngopharyngeal reflux. Objective: To compare the salivary transforming growth factor alpha levels of patients with Sjögren's syndrome and laryngopharyngeal reflux to those of healthy controls. Methods: This is a prospective controlled study. Twelve patients with Sjögren's syndrome and laryngopharyngeal reflux and 11 controls were prospectively evaluated. Spontaneous and stimulated saliva samples were obtained to establish salivary transforming growth factor alpha concentrations. Results: The salivary transforming growth factor alpha levels of patients were significantly higher than those of healthy controls. Five patients with laryngopharyngeal reflux also had erosive esophagitis; their salivary transforming growth factor alpha levels were comparable to controls. Conclusion: Salivary transforming growth factor alpha level was significantly higher in patients with Sjögren's syndrome and laryngopharyngeal reflux when compared to the control group.

【 授权许可】

CC BY