The methanol sesquisolvate of sodium naproxen

Acta Crystallographica Section E: Crystallographic Communications

Jones, M.J.¹  Kriegner, H.²  Weil, M.³ 

[1] Co KG, St.-Peter-Strasse 25, A-4020 Linz, Austria;Institute for Chemical Technologies and Analytics, Division of Structural Chemistry, TU Wien, Getreidemarkt 9/164-SC, A-1060 Vienna, Austria;Patheon Austria GmbH &

关键词: CRYSTAL STRUCTURE;    SOLVATOMORPHISM;    NAPROXEN;    METHANOL SOLVATE;    DISORDER;   

DOI  :  10.1107/S2056989018014652

学科分类：数学（综合）

来源: International Union of Crystallography

【 摘 要 】

The asymmetric unit of the methanol solvate of sodium naproxen, systematic name: sodium (2S)-2-(6-meth­oxy­naphthalen-2-yl)propano­ate methanol sesquisolvate, Na+·C14H13O3−·1.5CH3OH, comprises two formula units of the mol­ecular salt and three methanol mol­ecules. One of the sodium cations exhibits a coordination number of six and is bonded to three carboxyl­ate O atoms and three methanol OH groups whereas the second sodium cation has a coordination number of seven, defined by five carboxyl­ate O atoms and two methanol OH groups. Both coordination polyhedra around the sodium cations are considerably distorted. The two types of cations are bridged into polymeric chains extending parallel to [010]. This arrangement is stabilized by intrachain O—H⋯O hydrogen bonds between methanol ligands as donor and carboxyl­ate O atoms as acceptor groups. The hydro­phobic 6-meth­oxy­naphthyl moieties flank the hydro­philic sodium oxygen chains into ribbons parallel to [010]. There are no noticeable inter­molecular inter­actions between these ribbons. One of the 6-meth­oxy­naphthyl moieties is disordered over two sets of sites in a 0.723 (3):0.277 (3) ratio.

【 授权许可】

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