Resistance to epidermal growth factor receptor tyrosine kinase inhibitors, T790M, and clinical trials

Current oncology

G.M. O’Kane¹ 

[1] Princess Margaret Cancer Centre

关键词: Lung cancer;    EGFR;    resistance;    T790M;   

DOI  :  10.3747/co.25.3796

学科分类：肿瘤学

来源: Multimed, Inc.

【 摘 要 】

Tumours with sensitizing mutations in theEGFRgene constitute a distinct molecular subgroup of non-small-cell lung cancers (nsclcs) that benefit from precision medicine. First- and second-generation epidermal growth factor receptor (egfr) tyrosine kinase inhibitors (tkis) are recommended as upfront therapy forEGFR- mutated advanced nsclc and, compared with chemotherapy, have resulted in superior progression-free survival, improved tumour response rates, and improved quality of life. However, resistance inevitably develops, and the third-generation tki osimertinib has been approved to target the gatekeeperEGFRmutation T790M, which is responsible for resistance in 60% of cases. Multiple drivers of tki resistance have now been identified, and many new drugs are in development. With respect to this rapidly evolving field, our review highlights the current status of treatment options for patients withEGFR- mutated advanced nsclc, focusing especially on identified causes of resistance, challenges, and clinical trials aiming to improve outcomes in this patient population.

【 授权许可】

Unknown