The metabolic modulator PGC-1α in cancer

American Journal of Cancer Research

Frederic Bost¹ 

[1] Universit Nice Cte dAzur, Inserm, C3M, Centre Mditerranen de Mdecine Molculaire (INSERM U1065), Nice, France

关键词: PGC1 alpha;    prostate cancer;    melanoma;    breast cancer;    pancreatic cancer;    metabolism;    mitochondria;   

DOI  :  

学科分类：肿瘤学

来源: e-Century Publishing Corporation

【 摘 要 】

The peroxisome proliferator-activated receptor gamma coactivator 1 alpha (PGC-1α) is a central modulator of cell metabolism. It regulates mitochondrial biogenesis and oxidative metabolism. Modifications and adaptations in cellular metabolism are hallmarks of cancer cells, thus, it is not surprising that PGC-1α plays a role in cancer. Several recent articles have shown that PGC-1α expression is altered in tumors and metastasis in relation to modifications in cellular metabolism. The potential uses of PGC-1α as a therapeutic target and a biomarker of the advanced form of cancer will be summarized in this review.

【 授权许可】

CC BY-NC