Ruthenium Oxide pH Sensing for Organs-On-Chip Studies

Proceedings

Olthuis, Wouter¹  Tanumihardja, Esther²  Berg, Albert van den³ 

[1] Author to whom correspondence should be addressed.;BIOS Lab on a Chip group, Technical Medical Centre, MESA+ Institute for Nanotechnology, and Max Planck Center for Complex Fluid Dynamics, University of Twente, 7522 NB Enschede, The Netherlands;Presented at the Eurosensors 2018 Conference, Graz, Austria, 9–12 September 2018.

关键词: ruthenium oxide;    potentiometric sensor;    pH sensor;    organs-on-chip;    lab-on-chip;   

DOI  :  10.3390/proceedings2130709

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

A ruthenium oxide (RuOx) electrode is being developed as potentiometric pH sensor for organs-on-chip applications. Open-circuit potential (OCP) of the RuOx electrode showed a response of −58.05 mV/pH, with no cross-sensitivity to potentially interfering/complexing ions (tested were lithium, sulfate, chloride, and calcium ions). Similar response was observed in complex biological medium. The electrode stored in liquid had a long-term drift of −0.8 mV/hour (corresponding to ΔpH of 0.013/hour) and response time in complex biological medium was 3.7 s. Minimum cross-sensitivity to oxygen was observed as the OCP shifted ~3 mV going from deoxygenated to oxygenated solution. This response is one magnitude lower than previously reported for metal- oxide pH sensors. Overall, the RuOx pH sensor has proven to be a suitable pH sensor for organs- on-chip applications.

【 授权许可】

CC BY