The Effects of Apigenin and Curcumin on Autophagy Related Cell Death and Apoptosis

Proceedings

Dagistanli, Fatma Kaya¹  Kayacan, Sera²  Yilancioglu, Kaan³  Akdemir, Ayse Seda⁴  Melikoglu, Gulay⁵ 

[1] Author to whom correspondence should be addressed.;Department of Medical Biology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul 34098, Turkey;Department of Molecular Biology and Genetics, Bioengineering Faculty, Uskudar University, Istanbul 34662, Turkey;Department of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey;Presented at the 2nd International Cell Death Research Congress, Izmir, Turkey, 1–4 November 2018

关键词: curcumin;    apigenin;    apoptosis;    autophagy related cell death;    HeLa cells;   

DOI  :  10.3390/proceedings2251586

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

Cervical cancer is one of the frequent types of cancer seen in females. It has been suggested that natural compounds can be used effectively for cancer treatment. Apoptosis and autophagy related cell death play important roles in suppression of tumorigenesis. Apigenin and curcumin are natural products isolated from plant extracts known to have antitumoral, antibacterial and antiviral effects. Varying doses of curcumin and apigenin were applied to HeLa cancer cell lines. The expression of the genes related to apoptosis and/or autophagy related cell death were measured using qRT-PCR and cell viability was measured using MTT assay. Our results showed that curcumin and apigenin are effective on apoptosis and autophagy related cell death in HeLa cells. We suggested that these natural products seem to be a new promising therapeutic approach in cancer.

【 授权许可】

CC BY