Cavitation-Assisted Micromixing for Polymeric Nanoparticle Generation

Proceedings

Donno, Roberto¹  Surdo, Salvatore²  Geven, Mike Alexander³  Diaspro, Alberto⁴ 

[1] Author to whom correspondence should be addressed.;Nanophysics, Istituto Italiano di Tecnologia, 16163 Genova, Italy;Polymers and Biomaterials, Istituto Italiano di Tecnologia, 16163 Genova, Italy;Presented at the Eurosensors 2018 Conference, Graz, Austria, 9–12 September 2018

关键词: phase-separation;    high-throughput;    microfluidics;    cavitation bubbles;    PLGA;   

DOI  :  10.3390/proceedings2130942

学科分类：社会科学、人文和艺术（综合）

来源: mdpi

【 摘 要 】

The high-throughput generation of polymeric nanoparticles (PNPs) with tailored size and narrow size distribution is key for applications as relevant as sensing and nanomedicine. Here we show how cavitation bubbles in a microfluidic channel can induce rapid nanoprecipitation of PNPs with user-selectable control. Specifically, we used two tip-electrodes perpendicular to the flow to induce electrical breakdown of a polymer solution and a miscible non-solvent. As a result, a plasma is formed causing cavitation and rapid mixing of the fluids, yielding nanoprecipitates of polymer. We demonstrated mL/min generation of PNPs with a diameter as low as 150 nm and polydispersity below 0.15.

【 授权许可】

CC BY