Linking stem cell function and growth pattern of intestinal organoids

Developmental biology

Marianne Quaas^1,2¹  Maria Herberg^1²  Ulf-Dietrich Braumann^3,4³  Christiane Kerner^2⁴  Torsten Thalheim^1⁵ 

[1]Department of Surgery, Research Laboratories, Leipzig University, .Liebigstr. 19, 04103 Leipzig, Germany^2

[2]Faculty of Electrical Engineering and Information Technology, Leipzig University of Applied Sciences (HTWK), Wächterstraße 13, 04107 Leipzig, Germany^3

[3]Fraunhofer Institute for Cell Therapy and Immunology (IZI), Perlickstraße 1, 04103 Leipzig, Germany^4

[4]Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Haertelstr. 16-18, 04107 Leipzig, Germany^5

[5]Interdisciplinary Centre for Bioinformatics, Leipzig University, Haertelstr. 16-18, 04107 Leipzig, Germany^1

关键词: Intestinal stem cell;    Organoid culture;    Computational modeling;    Wnt;    Notch;   

DOI  :  10.1016/j.ydbio.2017.10.013

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Intestinal stem cells (ISCs) require well-defined signals from their environment in order to carry out their specific functions. Most of these signals are provided by neighboring cells that form a stem cell niche, whose shape and cellular composition self-organize. Major features of this self-organization can be studied in ISC-derived organoid culture. In this system, manipulation of essential pathways of stem cell maintenance and differentiation results in well-described growth phenotypes.

【 授权许可】

CC BY