sox2 and sox3 Play unique roles in development of hair cells and neurons in the zebrafish inner ear

Developmental biology

Yunzi Gou^1¹ 

[1] Department of Biology, Texas A&M University, College Station, TX 77843-3258, USA^1

关键词: SoxB1;    Sensory epithelia;    Statoacoustic ganglion;    Otic placode;   

DOI  :  10.1016/j.ydbio.2018.01.010

学科分类：生物科学（综合）

来源: Academic Press

【 摘 要 】

Formation of neural and sensory progenitors in the inner ear requires Sox2 in mammals, and in other species is thought to rely on both Sox2 and Sox3. How Sox2 and/or Sox3 promote different fates is poorly understood. Our mutant analysis in zebrafish showed that sox2 is uniquely required for sensory development while sox3 is uniquely required for neurogenesis.

【 授权许可】

CC BY