Reduced prefrontal hemodynamic response in pediatric autism spectrum disorder measured with near-infrared spectroscopy

Child and Adolescent Psychiatry and Mental Health

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[1] 0000 0004 0372 782X, grid.410814.8, Department of Psychiatry, Nara Medical University, 840 Shijyo-cho, 634-8522, Kashihara, Nara, Japan;0000 0004 0372 782X, grid.410814.8, Faculty of Nursing, Nara Medical University, Kashihara, Japan;Department of Psychiatry, Manyo Hospital, Kashihara, Japan;

关键词: Pediatric autism spectrum disorder;    Near-infrared spectroscopy;    Prefrontal hemodynamic response;    Attention;    Executive function;   

DOI  :  10.1186/s13034-019-0289-9

来源: publisher

【 摘 要 】

BackgroundFunctional neuroimaging studies suggest that prefrontal cortex dysfunction is present in people with autism spectrum disorder (ASD). Near-infrared spectroscopy is a noninvasive optical tool for examining oxygenation and hemodynamic changes in the cerebral cortex by measuring changes in oxygenated hemoglobin.MethodsTwelve drug-naïve male participants, aged 7–15 years and diagnosed with ASD according to DSM-5 criteria, and 12 age- and intelligence quotient (IQ)-matched healthy control males participated in the present study after giving informed consent. Relative concentrations of oxyhemoglobin were measured with frontal probes every 0.1 s during the Stroop color-word task, using 24-channel near-infrared spectroscopy.ResultsOxyhemoglobin changes during the Stroop color-word task in the ASD group were significantly smaller than those in the control group at channels 12 and 13, located over the dorsolateral prefrontal cortex (FDR-corrected P: 0.0021–0.0063).ConclusionThe results suggest that male children with ASD have reduced prefrontal hemodynamic responses, measured with near-infrared spectroscopy.

【 授权许可】

CC BY