期刊论文详细信息
Particle and Fibre Toxicology
Developmental programming of obesity by maternal exposure to concentrated ambient PM2.5 is maternally transmitted into the third generation in a mouse model
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[1] 0000 0001 0125 2443, grid.8547.e, Department of Environmental Health, School of Public Health, Fudan University, 130 Dong’an Rd, 200032, Shanghai, China;0000 0001 0125 2443, grid.8547.e, Department of Environmental Health, School of Public Health, Fudan University, 130 Dong’an Rd, 200032, Shanghai, China;Shanghai Key Laboratory of Meteorology and Health, Shanghai Meteorological Service, Shanghai, China;0000 0001 0125 2443, grid.8547.e, NHC Key Laboratory of Reproduction Regulation (Shanghai Institute of Planned Parenthood Research), Fudan University, Shanghai, China;0000 0001 2175 4264, grid.411024.2, Department of Medicine Cardiology Division, University of Maryland School of Medicine, 20 Penn St. HSFII S005, 21201, Baltimore, MD, USA;Department of Interventional & Vascular Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China;Shanghai Key Laboratory of Meteorology and Health, Shanghai Meteorological Service, Shanghai, China;
关键词: PM;    Maternal exposure;    Obesity;    Developmental programming;    Cross-generational transmission;   
DOI  :  10.1186/s12989-019-0312-6
来源: publisher
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【 摘 要 】

BackgroundObesity is an uncontrolled global epidemic and one of the leading global public health challenges. Maternal exposure to ambient fine particulate matter (PM2.5) may adversely program offspring’s adiposity, suggesting a specialized role of PM2.5 pollution in the global obesity epidemic. However, the vulnerable window for this adverse programming and how it is cross-generationally transmitted have not been determined. Therefore, in the present study, female C57Bl/6 J mice were exposed to filtered air (FA) or concentrated ambient PM2.5 (CAP) during different periods, and the development and adulthood adiposity of their four-generational offspring were assessed.ResultsOur data show that the pre-conceptional but not gestational exposure to CAP was sufficient to cause male but not female offspring’s low birth weight, accelerated postnatal weight gain, and increased adulthood adiposity. These adverse developmental traits were transmitted into the F2 offspring born by the female but not male F1 offspring of CAP-exposed dams. In contrast, no adverse development was noted in the F3 offspring.ConclusionsThe present study identified a pre-conceptional window for the adverse programming of adiposity by maternal exposure to PM2.5, and showed that it was maternally transmitted into the third generation. These data not only call special attention to the protection of women from exposure to PM2.5, but also may facilitate the development of intervention to prevent this adverse programming.

【 授权许可】

CC BY   

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