Takotsubo cardiomyopathy in cancer patients

Cardio-Oncology

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[1] Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA;Department of Medicine, University of Connecticut School of Medicine, Farmington, CT, USA;0000000419370394, grid.208078.5, Department of Medicine, Division of Cardiology, University of Connecticut School of Medicine, 263 Farmington Avenue, 06030-2202, Farmington, CT, USA;

关键词: Chemotherapy;    Takotsubo cardiomyopathy;    Stress cardiomyopathy;    Cancer;   

DOI  :  10.1186/s40959-019-0042-9

来源: publisher

【 摘 要 】

BackgroundCancer is a chronic condition that induces significant emotional and physical stress, which may increase the risk for developing Takotsubo cardiomyopathy (TCM).Main bodyTakotsubo cardiomyopathy, also known as stress cardiomyopathy, is a clinical syndrome that generally presents as chest pain mimicking acute coronary syndrome or as an acute heart failure characterized by severe left ventricular systolic dysfunction in response to emotional, physical, or medical stress. The potential triggers for Takotsubo syndrome in cancer patients include the emotional turmoil of a cancer diagnosis, the inflammatory state of the cancer itself, and the physical stress of cancer surgery, systemic anti-neoplastic therapy, and radiation treatment. TCM is becoming increasingly recognized among patients with cancer and has been associated with adverse outcomes in this patient population. In this study, we searched the Pubmed database using keywords “Takotsubo cardiomyopathy”, “cancer”, and “anti-neoplastic therapy” to review case reports of Takotsubo syndrome occurring in oncologic patients after systemic anti-neoplastic therapy. Clinical presentation, electrocardiogram, laboratory data, transthoracic echocardiogram and coronary angiogram results, and patient outcomes were collected and analyzed.ConclusionPatients with cancer are at an elevated risk for developing stress cardiomyopathy, and it is important to know which cancer drugs have been associated with the development of the Takotsubo syndrome.

【 授权许可】

CC BY