High prevalence and heterogeneity of Dysglycemia in patients with tuberculosis from Peru: a prospective cohort study

BMC Infectious Diseases

  ^{1    2    3    4    5    5    5    6    7} 

[1] 0000 0004 0372 8259, grid.8399.b, Faculdade de Medicina, Universidade Federal da Bahia, 40110-100, Salvador, Bahia, Brazil;Instituto Brasileiro para Investigação da Tuberculose, Fundação José Silveira, 40210-320, Salvador, Bahia, Brazil;0000 0001 0723 0931, grid.418068.3, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40269-710, Salvador, Bahia, Brazil;Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, 40210-320, Salvador, Bahia, Brazil;0000 0004 0372 8259, grid.8399.b, Faculdade de Medicina, Universidade Federal da Bahia, 40110-100, Salvador, Bahia, Brazil;Instituto Brasileiro para Investigação da Tuberculose, Fundação José Silveira, 40210-320, Salvador, Bahia, Brazil;0000 0001 0723 0931, grid.418068.3, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz, 40269-710, Salvador, Bahia, Brazil;Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, 40210-320, Salvador, Bahia, Brazil;0000 0004 0471 7789, grid.467298.6, Curso de Medicina, Faculdade de Tecnologia e Ciências, 41741-590, Salvador, Bahia, Brazil;Universidade Salvador (UNIFACS), Laureate University, 41720-200, Salvador, Bahia, Brazil;0000 0004 0398 2863, grid.414171.6, Escola Bahiana de Medicina e Saúde Pública, 40290-000, Salvador, Bahia, Brazil;0000 0004 0372 8259, grid.8399.b, Faculdade de Medicina, Universidade Federal da Bahia, 40110-100, Salvador, Bahia, Brazil;Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, 40210-320, Salvador, Bahia, Brazil;Multinational Organization Network Sponsoring Translational and Epidemiological Research (MONSTER) Initiative, Fundação José Silveira, 40210-320, Salvador, Bahia, Brazil;0000 0004 0471 7789, grid.467298.6, Curso de Medicina, Faculdade de Tecnologia e Ciências, 41741-590, Salvador, Bahia, Brazil;Socios En Salud Sucursal Peru, 15001, Lima, Peru;Socios En Salud Sucursal Peru, 15001, Lima, Peru;0000 0001 2294 473X, grid.8536.8, Faculdade de Medicina, Universidade Federal do Rio de Janeiro, 21941-590, Rio de Janeiro, Brazil;Socios En Salud Sucursal Peru, 15001, Lima, Peru;000000041936754X, grid.38142.3c, Department of Global Health and Social Medicine, Harvard Medical School, 02115, Boston, MA, USA;

关键词: Diabetes mellitus;    Prediabetes;    Tuberculosis;    Comorbidity;    Prevalence;   

DOI  :  10.1186/s12879-019-4416-2

来源: publisher

【 摘 要 】

BackgroundThe accuracy of different laboratory tests for diagnosis of diabetes mellitus (DM) and prediabetes (preDM) in populations exposed to tuberculosis (TB) remains poorly understood. Here, we examined the prevalence of DM and preDM in TB affected people in Lima, Peru.MethodsA prospective cohort study of patients affected TB and their household contacts (HHC), was conducted between February and November 2017 in Lima, Peru. Fasting plasma glucose (FPG), HbA1c and oral glucose tolerance test (OGTT) were used to detect DM and preDM in a prospective cohort of TB patients (n = 136) and household contacts (n = 138). Diagnostic performance of the laboratory tests was analyzed. Potential effects of sociodemographic and clinical factors on detection of dysglycemia were analyzed.ResultsIn TB patients, prevalence of DM and preDM was 13.97 and 30.88% respectively. Lower prevalence of both DM (6.52%) and preDM (28.99%) were observed in contacts. FPG, HbA1c and OGTT had poor agreement in detection of preDM in either TB cases or contacts. TB-DM patients had substantially lower hemoglobin levels, which resulted in low accuracy of HbA1c-based diagnosis. Classic sociodemographic and clinical characteristics were not different between TB patients with or without dysglycemia.ConclusionHigh prevalence of DM and preDM was found in both TB patients and contacts in Lima. Anemia was strongly associated with TB-DM, which directly affected the diagnostic performance of HbA1c in such population.

【 授权许可】

CC BY