Adverse drug reactions experienced by out-patients taking chlorpromazine or haloperidol at Zomba Mental Hospital, Malawi

BMC Research Notes

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[1] 0000 0001 2113 2211, grid.10595.38, Medical Laboratory Sciences, College of Medicine, University of Malawi, Blantyre, Malawi;0000 0001 2113 2211, grid.10595.38, Pharmacy Department, College of Medicine, University of Malawi, Blantyre, Malawi;0000 0001 2294 5433, grid.412997.0, Department of Pharmacology, Government Medical College Srinagar, Srinagar, India;Zomba Mental Hospital, P.O. Box 38, Zomba, Malawi;

关键词: Adverse drug reactions;    Antipsychotic;    Chlorpromazine;    Haloperidol;    Malawi;    Mental health;   

DOI  :  10.1186/s13104-019-4398-6

来源: publisher

【 摘 要 】

ObjectiveDrugs for managing mental disorders can cause adverse drug reactions (ADRs) that have negative impacts on patients yet, in Malawi, epidemiological data on the drug-related problems are limited. This study assessed the prevalence and severity of ADRs in out-patients at Zomba Mental Hospital.ResultsTwenty-six of forty patients (65.0%) were taking haloperidol and 14 (35.0%) chlorpromazine. The commonest diagnosis was schizophrenia (n = 23, 57.5%) followed by epileptic psychosis (n = 4, 10.0%) and general psychosis (n = 4, 10.0%) with one of psychotic depression and one psychosis secondary to general medical condition. Comorbidities were also found with epilepsy being the commonest (n = 4, 10.0%). All patients reported at least one ADR of varying severity (mild, moderate and severe). Polydipsia was the most prevalent (24, 60.0%) followed by weight gain (20, 50.0%), spasm (15, 37.5%) and xerostomia (15, 37.5%). Some ADRs were gender specific and these included impotence (6/27, 29.6%) for males and menstrual changes (3/14, 21.4%) for females. Severe ADRs were more common in the older aged group (> 35 years 8.3% vs 7.1%), in males (11.1% vs 0.0%) and on chlorpromazine (14.3% vs 3.8%). Patients taking chlorpromazine and haloperidol are at risk of experiencing a wide range of ADRs with varying degrees of severity.

【 授权许可】

CC BY