Relapse in patients with schizophrenia: a comparison between risperidone and haloperidol

Revista Brasileira de Psiquiatria

Eduardo Pondé De Sena¹  Rogério Santos-jesus¹  Ângela Miranda-scippa¹  Lucas De Castro Quarantini¹  Irismar Reis De Oliveira¹ 

[1] ,Federal University of Bahia University Hospital Prof. Edgard Santos Salvador BA ,Brazil

关键词: Risperidone;    Haloperidol;    Antipsychotic;    Schizophrenia;    Relapse prevention;    Risperidona;    Haloperidol;    Antipsicótico;    Esquizofrenia;    Prevenção de recaída;   

DOI  :  10.1590/S1516-44462003000400007

来源: SciELO

【 摘 要 】

OBJECTIVES: To compare rates of rehospitalization and time to relapse in risperidone vs. haloperidol-treated schizophrenic patients discharged from the hospital. METHODS: Randomized controlled trial comparing risperidone and haloperidol regarding relapse in patients with schizophrenia treated with flexible doses during one year. RESULTS: Twenty patients were assigned to risperidone and 13 to haloperidol. One patient from each group withdrew consent and one patient in the risperidone group was lost for follow-up. Six (30.0%) patients in the risperidone group and 3 (23.1%) in the haloperidol group relapsed (p=1.00). However, time to relapse was shorter in the later (logrank =4.2; p=.04). When rehospitalized, patients in the risperidone group stayed 34.5 days (median) at hospital as compared to the haloperidol group (median of 61 days) (p=.61). CONCLUSION: The proportion of schizophrenic patients who relapsed was similar in both groups; However, time to relapse was shorter in the haloperidol-treated patients.

【 授权许可】

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