A Bayesian Dose-finding Design for Drug Combination Trials with Delayed Toxicities

Bayesian Analysis

Suyu Liu¹ 

关键词: Adaptive design;    Late-onset toxicity;    Combining drugs;    Missing data;    Maximum tolerated dose;    Phase I trial;   

DOI  :  10.1214/13-BA839

学科分类：统计和概率

来源: Institute of Mathematical Statistics

【 摘 要 】

We propose a Bayesian adaptive dose-finding design for drug combination trials with delayed toxicity. We model the dose-toxicity relationship using the Finney model, a model widely used in drug-drug interaction studies. The intuitive interpretations of th

【 授权许可】

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