期刊论文详细信息
Genetics: A Periodical Record of Investigations Bearing on Heredity and Variation
Development and Function of the Drosophila Tracheal System
article
Shigeo Hayashi1  Takefumi Kondo3 
[1] Laboratory for Morphogenetic Signaling, RIKEN Center for Developmental Biology, Kobe, Hyogo 650-0047, Japan;Department of Biology, Kobe University Graduate School of Science, Nada-ku, Hyogo 657-8501, Japan;Graduate School of Biostudies, Kyoto University, Kyoto, Sakyo-ku 606-8501, Japan;The Keihanshin Consortium for Fostering the Next Generation of Global Leaders in Research (K-CONNEX), Kyoto, Sakyo-ku 606-8501, Japan
关键词: trachea;    development;    tubulogenesis;    branching;    physiology;    FlyBook;   
DOI  :  10.1534/genetics.117.300167
学科分类:医学(综合)
来源: Genetics Society of America
PDF
【 摘 要 】

The tracheal system of insects is a network of epithelial tubules that functions as a respiratory organ to supply oxygen to various target organs. Target-derived signaling inputs regulate stereotyped modes of cell specification, branching morphogenesis, and collective cell migration in the embryonic stage. In the postembryonic stages, the same set of signaling pathways controls highly plastic regulation of size increase and pattern elaboration during larval stages, and cell proliferation and reprograming during metamorphosis. Tracheal tube morphogenesis is also regulated by physicochemical interaction of the cell and apical extracellular matrix to regulate optimal geometry suitable for air flow. The trachea system senses both the external oxygen level and the metabolic activity of internal organs, and helps organismal adaptation to changes in environmental oxygen level. Cellular and molecular mechanisms underlying the high plasticity of tracheal development and physiology uncovered through research on Drosophila are discussed.

【 授权许可】

CC BY   

【 预 览 】
附件列表
Files Size Format View
RO201907120005807ZK.pdf 877KB PDF download
  文献评价指标  
  下载次数:6次 浏览次数:0次