Journal of Applied Biomedicine | |
RGD peptide doped polypyrrole film as a biomimetic electrode coating for impedimetric sensing of cell proliferation and cytotoxicity | |
关键词: RGD peptide; Polypyrrole; Cell-based sensor; Proliferation; Cytotoxicity; Electrochemical impedance microscopy; | |
DOI : 10.1016/j.jab.2017.06.001 | |
学科分类:医学(综合) | |
来源: Elsevier | |
【 摘 要 】
A novel and facile in vitro cell sensing system has been developed with one-step electropolymerization of the conducting polypyrrole(PPy) polymer using RGD peptide as the sole dopant on an indium tin oxide (ITO) surface. The resulted RGD peptide-doped polypyrrole (PPy/RGD) composite film had a robust surface, in which PPy provided a biocompatible matrix for cell growth and a conducting interface for electrical detection, while the RGD peptide entrapped in the PPy matrix conferred the desired biomimetic properties. Using the human lung cancer cell A549 as a model, this system can be used to monitor cell behaviors of proliferation and cytotoxicity.
【 授权许可】
Unknown
【 预 览 】
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RO201904282121396ZK.pdf | 2551KB | download |