The ability of usage various RGD configurations for the biodegradable vascular graft modification

International Scientific and Technical Youth Conference "Perspective Materials of Constructional and Medical Purpose"

材料科学;医药卫生

Antonova, L.V.^1 ; Krivkina, E.O.^1 ; Senokosova, E.A.^1 ; Silnikov, V.N.^2 ; Velikanova, E.A.^1 ; Glushkova, T.V.^1

Research Institute for Complex Issues of Cardiovascular Diseases, Kemerovo, Russia^1

Institute of Chemical Biology and Fundamental Medicine, Siberian Branch of Russian Academy of Sciences, Novosibirsk, Russia^2

关键词: Human umbilical vein endothelial cells;    Non-woven;    Polyhydroxybutyrate;    RGD peptide;    Vascular grafts;   

Others  :  https://iopscience.iop.org/article/10.1088/1757-899X/511/1/012036/pdf
DOI  :  10.1088/1757-899X/511/1/012036

来源: IOP

【 摘 要 】

The results of modifying non-woven matrices based on polyhydroxybutyrate/valerate and polycaprolactone with various RGD peptides (peptides: RGDK, AhRGD, c[RGDFK]) attached to the surface of matrices using hexamethylenediamine were studied. The structure of the surface of the matrices before and after the modification was not significantly changed. After 7 days of cultivation, the largest number of adherent and viable human umbilical vein endothelial cells of a person were detected on the surface of matrices with AhRGD or c[RGDFK]. However, cell proliferation was practically absent on the matrices with AhRGD. Thus, the modification of the surface of matrices with the AhRGD peptide is most suitable for products requiring rapid endothelization.