The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and ER

Current Health Sciences Journal

Oana Sorina Tica ; A. Comanescu ; Maria Bogdan ; D.O. Alexandru ; A.A. Tica ; T. Ciurea

关键词: GPER;    ER;    myometrium;    contraction;    G1;   

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

GPER (G protein coupled estrogen receptor 1), a particular estrogen binding site, is ubiquitously present in human tissues, but its precise physiological role is still very disputed. GPER is associated with normal and abnormal estrogen-dependent proliferations in female tissues and is involved in generation of rapid estrogenic answers. A very important fact is that GPER-induced genomic effects are additive to those mediated by lassic?estrogen receptors, but regarding the rapid effects, as we prove in this study, these can be significant different or even antagonistic.

【 授权许可】

Unknown