The Estrogen-Induced Effects on Myometrium Are the Result of Activation of Two Different Receptor Types: GPER and Erα

Current Health Sciences Journal

OANA SORINA TICAreplacement¹ 

关键词: GPER;    ERα;    myometrium;    contraction;    G1;   

DOI  :  10.12865/CHSJ.41.03.03

学科分类：医学（综合）

来源: Universitatea de Medicina si Farmacie din Craiova / University of Medicine and Pharmacy

【 摘 要 】

GPER (G protein coupled estrogen receptor 1), a particular estrogen binding site, is ubiquitously present in human tissues, but its precise physiological role is still very disputed. GPER is associated with normal and abnormal estrogen-dependent proliferations in female tissues and is involved in generation of rapid estrogenic answers. A very important fact is that GPER-induced genomic effects are additive to those mediated by “classic” estrogen receptors, but regarding the rapid effects, as we prove in this study, these can be significant different or even antagonistic.

【 授权许可】

Unknown