| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Molecular chaperones and protein‐folding catalysts as intercellular signaling regulators in immunity and inflammation | |
| 关键词: Hsp60; Hsp70; microbial contamination; | |
| DOI : 10.1189/jlb.1209779 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Thisreviewcriticallyexaminesthehypothesisthatmolecularchaperonesandprotein‐foldingcatalystsfromprokaryotesandeukaryotescanbesecretedbycellsandfunctionasintercellularsignals,principallybutnotexclusively,forleukocytes.Agrowingnumberofmolecularchaperoneshavebeenreportedtofunctionasligandsforselectedreceptorsand/orreceptorsforspecificligands.Molecularchaperonesinitiallyappearedtoactprimarilyasstimulatorysignalsforleukocytesandthus,wereseenasproinflammatorymediators.However,evidenceisnowemergingthatmolecularchaperonescanhaveanti‐inflammatoryactionsor,dependingontheproteinandconcentration,anti‐andproinflammatoryfunctions.Recastingtheoriginalhypothesis,weproposethatmolecularchaperonesandprotein‐foldingcatalystsare“moonlighting”proteinsthatfunctionashomeostaticimmuneregulatorsbutmayalsoundercertaincircumstances,contributetotissuepathology.Oneofthekeyissuesinthefieldofmolecularchaperonebiologyrelatestotheroleofmicrobialcontaminantsintheirsignalingactivity;thistoowillbeevaluatedcritically.Themostfascinatingaspectofmolecularchaperonesprobablyrelatestoevidencefortheirtherapeuticpotentialinhumandisease,andongoingstudiesareevaluatingthispotentialinarangeofclinicalsettings...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904049972082ZK.pdf | 675KB |  download |
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