At the Bench: Understanding group 2 innate lymphoid cells in disease

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: ILC2;    allergy;    asthma;    atopic dermatitis;   

DOI  :  10.1189/jlb.5BT0814-374R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Theconventionalparadigmoftype2inflammatoryresponsesischaracterizedbyactivationofCD4+Th2cellsthatproduceIL‐4,IL‐5,andIL‐13,resultingintissueeosinophilinfiltration,mucusmetaplasia,AHR,andIgEproduction.However,therecentdiscoveryofILC2sinmiceandhumanshasbroughtforthanovelpathwayintype2immunitythatmayworkindependentof,orinconcertwith,adaptiveTh2responses.ILC2sweredescribedinitiallyaslineage‐negativelymphocytesthatproducehighlevelsofTh2cytokinesIL‐5andIL‐13inresponsetoIL‐25andIL‐33andpromoteprotectionagainsthelminthinfections.Morerecentinvestigationshaveidentifiednovelupstreamregulators,aswellasnovelILC2products.ILC2sarefoundinmucosalsurfaces,includingrespiratorytractandskin,andstudiesfromexperimentalasthmaandatopicdermatitismodelssupportaroleforILC2sinpromotingtype2inflammatoryresponses.TherearemanyunansweredquestionsabouttheroleofILC2sinchronicallergicdiseases,includinghowILC2sorupstreampathwayscanbetargetedfortherapy.AsILC2sarenotantigenspecificandmaybeactivatedafterexposurestoavarietyofinfectiousagentsandirritantsthoughttocontributetorespiratoryandskindiseases,futurestrategiestotargetILC2functioninhumandiseasemaybepromising.OurintentistoidentifypriorityareasforILC2translationalresearchbasedonbasicresearchinsights...

【 授权许可】

CC BY