The signaling symphony: T cell receptor tunes cytokine‐mediated T cell differentiation

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: pathway crosstalk;    signal rheostat;    proliferation;    homeostasis;    effector function;   

DOI  :  10.1189/jlb.1RI0614-293R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Tcelldevelopment,differentiation,andmaintenanceareorchestratedby2keysignalingaxes:theantigen‐specificTCRandcytokine‐mediatedsignals.TheTCRsignalstherecognitionofself‐andforeignantigenstocontrolTcellhomeostasisforimmunetoleranceandimmunity,whichisregulatedbyavarietyofcytokinestodetermineTcellsubsethomeostasisanddifferentiation.TCRsignalingcansynergizewithorantagonizecytokine‐mediatedsignalingtofinetuneTcellfate;however,thelatterislessinvestigated.MurinemodelswithattenuatedTCRsignalingstrengthhaverevealedthatTCRsignalingcanfunctionasregulatoryfeedbackmachineryforTcellhomeostasisanddifferentiationindifferentialcytokinemilieus,suchasIL‐2‐mediatedTregdevelopment;IL‐7‐mediated,nai¨veCD8+Tcellhomeostasis;andIL‐4‐inducedinnatememoryCD8+Tcelldevelopment.Inthisreview,wediscussthesymphoniccross‐talkbetweenTCRandcytokine‐mediatedresponsesthatdifferentiallycontrolTcellbehavior,withafocusonthenegativetuningbyTCRactivationonthecytokineeffects...

【 授权许可】

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