Loss of Estrogen Receptor α Signaling Leads to Insulin Resistance and Obesity in Young and Adult Female Mice

Cardiorenal medicine

Camila Manrique ; Guido Lastra ; Javad Habibi ; Irina Mugerfeld ; Mona Garro ; James R. Sowers

关键词: Skeletal muscle;    Estrogen;    Insulin resistance;   

DOI  :  10.1159/000339563

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract Background/Aims: There are important sex-related differences in the prevalence of obesity, type 2 diabetes mellitus and cardiovascular disease. Indeed, premenopausal women have a lower prevalence of these conditions relative to age-matched men. Estrogen participates in the modulation of insulin sensitivity, energy balance, and body composition. In this paper, we investigated the impact of estrogen signaling through estrogen receptor(ER) on systemic insulin sensitivity and insulin sign.

【 授权许可】

CC BY