| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Eosinophil crystalloid granules: structure, function, and beyond | |
| 关键词: allergy; inflammation; cytokine; chemokine; | |
| DOI : 10.1189/jlb.0212067 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Eosinophilsaregranulocytesassociatedwithhostdefenseagainstparasitichelminthswithallergicconditionsandmorerecently,withimmunoregulatoryresponses.Eosinophilsaredistinguishedfromleukocytesbytheirdominantpopulationofcytoplasmiccrystalloid(alsotermedsecretory,specific,orsecondary)granulesthatcontainrobuststoresofdiverse,preformedcationicproteins.Here,weprovideanupdateonourknowledgeabouttheuniqueandcomplexstructureofhumaneosinophilcrystalloidgranules.Wediscusstheirsignificanceasrichsitesofavarietyofreceptorsandreviewourownrecentresearchfindingsandthoseofothersthathighlightdiscoveriesconcerningthefunctionofintracellularreceptorsandtheirpotentialimplicationsincellsignaling.Specialfocusisprovidedonhoweosinophilsmightusetheseintracellularreceptorsasmechanismstosecrete,selectivelyandrapidly,cytokinesorchemokinesandenablecell‐freeextracellulareosinophilgranulestofunctionasindependentsecretorystructures.Potentialrolesofcell‐freeeosinophilgranulesasimmuneplayersintheabsenceofintacteosinophilswillalsobediscussed...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904049025515ZK.pdf | 340KB |  download |
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