| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Big insights from small volumes: deciphering complex leukocyte behaviors using microfluidics | |
| 关键词: nanotechnology; inflammation; neutrophils; dendritic cells; monocytes; | |
| DOI : 10.1189/jlb.5RU0216-056R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Inflammationisanindispensablecomponentoftheimmuneresponse,andleukocytesprovidethefirstlineofdefenseagainstinfection.Althoughthemajorstereotypicleukocytebehaviorsinresponsetoinfectionarewellknown,thecomplexitiesandidiosyncrasiesofthesephenotypesinconditionsofdiseasearestillemerging.Noveltoolsareindispensableforgaininginsightsintoleukocytebehavior,andinthepastdecade,microfluidictechnologieshaveemergedasanexcitingdevelopmentinthefield.Microfluidicdevicesarereadilycustomizable,providetightcontrolofexperimentalconditions,enablehighprecisionofexvivomeasurementsofindividualaswellasintegratedleukocytefunctions,andhavefacilitatedthediscoveryofnovelleukocytephenotypes.Here,wereviewsomeofthemostinterestinginsightsresultingfromtheapplicationofmicrofluidicapproachestothestudyoftheinflammatoryresponse.Theaimistoencourageleukocytebiologiststointegratethesenewtoolsintoincreasinglymoresophisticatedexperimentaldesignsforprobingcomplexleukocytefunctions...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904048369055ZK.pdf | 1936KB |  download |
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