Immune cells are associated with mortality: the Health and Retirement Study

Frontiers in Immunology

Immunology

Gokul Seshadri¹  Sithara Vivek¹  Anna Prizment¹  Bharat Thyagarajan²  Weihua Guan³  Eileen M. Crimmins⁴  Eric T. Klopack⁴  Helen C. S. Meier⁵  Jessica Faul⁵ 

[1] Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States;Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, United States;Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States;Division of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, United States;Leonard Davis School of Gerontology, University of Southern California, Los Angeles, CA, United States;Survey Research Center, Institute for Social Research, University of Michigan, Ann Arbor, MI, United States;

关键词: T-cells;    B-cells;    dendritic cells;    NK cells;    neutrophils;    inflammation;    mortality;    Health and Retirement Study;   

DOI  :  10.3389/fimmu.2023.1280144

 received in 2023-08-19, accepted in 2023-10-06,  发布年份 2023

来源: Frontiers

【 摘 要 】

IntroductionAge-related immunosenescence is characterized by changes in immune cell subsets and is associated with mortality. However, since immunosenescence is associated with other concurrent age-related changes such as inflammation and multi-organ dysfunction, it is unclear whether the association between age-related immunosenescence and mortality is independent of other concurrent age-related changes. To address these limitations, we evaluated the independent association between immune cell subsets and mortality after adjustment for age-related inflammation and biologic age.MethodsData for this study was obtained from the 2016 interview of the Health and Retirement Study (N=6802). Cox proportional hazards regression models were used to estimate the association between 25 immune cell subsets (11 T-cell subsets, 4 B-cell subsets, 3 monocyte subsets, 3 natural killer cell subsets, 3 dendritic cell subsets, and neutrophils) and 4-year mortality adjusting for covariates such as the Klemera-Doubal algorithm biological age, chronological age, gender, race/ethnicity, BMI, smoking status, comorbidity index, CMV seropositivity, and inflammatory latent variable comprising C-reactive protein, and 4 cytokines (interleukin-10, interleukin-1 receptor antagonist, interleukin-6, and soluble tumor necrosis factor).ResultsFour hundred and seventy-six participants died during the study period with an overall median follow up time of 2.5 years. After controlling for covariates and adjustment for sample-weights, total T cells [HR: 0.86, p=0.004], NK CD56LO cells [HR: 0.88, p=0.005], and neutrophils [HR: 1.22, p=0.004] were significantly associated with mortality.ConclusionsThese findings support the idea that an aging immune system is associated with short-term mortality independent of age-related inflammation or other age-related measures of physiological dysfunction. If replicated in other external cohorts, these findings could identify novel targets for both monitoring and intervention to reduce the age-related mortality.

【 授权许可】

Unknown   
Copyright © 2023 Seshadri, Vivek, Prizment, Crimmins, Klopack, Faul, Guan, Meier and Thyagarajan