期刊论文详细信息
Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society
Th17 memory cells: live long and proliferate
关键词: autoimmunity;    CD4 T cell;    IL‐;    17;    pathogen;   
DOI  :  10.1189/jlb.0313113
学科分类:生理学
来源: Federation of American Societies for Experimental Biology
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【 摘 要 】

Thedevelopmentofimmunememoryisadouble‐edgedsword,helpingtomaintainhealthbypreventingrepeatedinfectionsbutalsodrivingchronicinflammationwhendysregulated.Th17cellsarenowwell‐knownasmajordriversofautoimmunediseasebutalsoplayrolesinprotectiveimmuneresponsesagainstpathogens.Thismini‐reviewwillfocusontherecentevidenceforlong‐lived,robustTh17memorycellpopulationsinmousemodelsandhumans,andtheirfunctionalrolesinmediatinghostprotectionandchronicdiseasestates...

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