IFN‐λ is able to augment TLR‐mediated activation and subsequent function of primary human B cells

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: interferon;    immunoglobulins;    IL‐;    29;    innate immunity;   

DOI  :  10.1189/jlb.3A0215-041RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Duringthepastdecade,increasedemphasishasbeenplacedonfindingalternativestoIFN‐α‐basedtherapies.Onesuchalternative,IFN‐λ,hasshowntherapeuticpromiseinavarietyofdiseases,butresearchofthisfamilyofcytokineshasbeenprimarilyfocusedontheirantiviralactivities.ThegoalofthepresentstudywastoinvestigatetheroleofIFN‐λintheregulationandmodulationofBcellfunction.Weshowthat,similartoIFN‐α,IFN‐λ1isabletoaugmentTLR‐mediatedBcellactivation,partiallyattributedtoanupregulationofTLR7expression,andthatbothnaϊveandmemoryBcellsexpressthelimitingtypeIIIIFNreceptorcomponent,IFN‐λR1.Furthermore,thisIFN‐λ‐enhancedBcellactivationresultedinincreasedcytokineandIgproductionduringTLR7challenge,mostprominentlyaftertheadditionofhelperTcellsignals.Ultimately,theseelevatedcytokineandIglevelscouldbepartiallyattributedtotheincreaseinproliferationofTLR7‐challengedBcellsbybothtypeIandtypeIIIIFNs.ThesefindingsdemonstratetheabilityofIFN‐λtoboosthumoralimmunity,animportantattributetoconsiderforfurtherstudiesonimmunitytopathogens,vaccinedevelopment,andongoingadvancementoftherapeuticstrategiesaimedatreplacingIFN‐α‐basedtreatmentswithIFN‐λ...

【 授权许可】

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