| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| The future of antiviral immunotoxins | |
| 关键词: immunodeficiency; infectious disease; virus; | |
| DOI : 10.1189/jlb.2MR1015-468R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Thereisaconstantneedfornewtherapeuticinterventionsinawiderangeofinfectiousdiseases.Overthepastfewyears,theimmunotoxinshaveenteredthestageaspromisingantiviraltreatments.ImmunotoxinshavebeenextensivelyexploredincancertreatmentandhaveachievedFDAapprovalinseveralcases.Indeed,thedesignofnewanticancerimmunotoxinsisarapidlydevelopingfield.However,atpresent,severalimmunotoxinshavebeendevelopedtargetingavarietyofdifferentviruseswithhighspecificityandefficacy.Ratherthanblockingaviralorcellularpathwayneededforvirusreplicationanddissemination,immunotoxinsexerttheireffectbykillinganderadicatingthepoolofinfectedcells.Bytargetingavirus‐encodedtargetmolecule,itispossibletoobtainsuperiorselectivityanddrasticallylimitthesideeffects,whichisanimmunotoxin‐relatedchallengethathashinderedthesuccessofimmunotoxinsincancertreatment.Therefore,itseemsbeneficialtouseimmunotoxinsforthetreatmentofvirusinfections.Onerecentexampleshowedthattargetingofvirus‐encoded7transmembrane(7TM)receptorsbyimmunotoxinscouldbeafuturestrategyfordesigningultraspecificantiviraltreatment,ensuringefficientinternalizationandhenceefficienteradicationofthepoolofinfectedcells,bothinvitroandinvivo.Inthisreview,weprovideanoverviewofthemechanismsofactionofimmunotoxinsandhighlighttheadvantagesofimmunotoxinsasfutureanti‐viraltherapies...
【 授权许可】
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【 预 览 】
| Files | Size | Format | View |
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| RO201904045383363ZK.pdf | 870KB |  download |
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