Neutrophils and macrophages work in concert as inducers and effectors of adaptive immunity against extracellular and intracellular microbial pathogens

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: adaptive immunity;    phagocytosis;    antimicrobial mechanisms;   

DOI  :  10.1189/jlb.1109767

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Emergingdatasuggestnewfacetsoftheconcertedparticipationofneutrophilsandmacrophagesinantimicrobialimmunity.TheclassicalviewisthatDCsandmacrophagesaretheinducersofadaptiveantimicrobialimmunity,butthereisevidenceforneutrophilparticipationinthistaskascytokineandchemokineproducersandAPCs.Ontheotherhand,theconceptthattheTH1responseisonlyassociatedwithcontrolofinfectionsbyintracellularpathogensthroughactivationofmacrophagesbyIFN‐γ,andtheTH17/IL‐17axisisonlyinvolvedinprotectionagainstextracellularpathogensthroughmobilizationandactivationofneutrophilsissimplistic:ThereisevidencesuggestingthatTH1andTH17responses,separatelyorinparallel,mayusemacrophagesandneutrophilsagainstinfectionsbyextracellularandintracellularmicrobialpathogens.Opsonizationbypathogen‐specificIgsenhancestheantimicrobialcapabilitiesofneutrophilsandmacrophagesininfectionsbyextracellularandintracellularmicrobes.Thefunctionalpartnershipbetweenmacrophagesandneutrophilsasinducersandeffectorsofadaptiveantimicrobialimmunityconformstotheiraffiliationwiththemyeloidphagocytesystemandrevealsastrategybasedontheconcurrentuseofthetwoprofessionalphagocytesintheadaptivedefensemechanisms.Startingfromacommonmyeloidprecursorinthebonemarrow,macrophagesandneutrophilssplitduringdifferentiationbutcometogetherattheinfectiousfociforacooperativestrategythatusesmodulatorandeffectoractivitiestoattackinvadingmicrobialpathogens...

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