Chemokine interaction with synergy‐inducing molecules: fine tuning modulation of cell trafficking

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: cell migration;    chemokine activities;    CXCL12;    HMGB1;   

DOI  :  10.1189/jlb.1MR1015-457R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Directedmigrationandarrestofleukocytesduringhomeostasis,inflammation,andtumordevelopmentismediatedbythechemokinesystem,whichgovernsleukocytemigrationandactivities.Althoughweunderstandwelltheeffectsofdifferentchemokinesonebyone,muchlesswasknownaboutthepotentialconsequencesoftheconcomitantexpressionofmultiplechemokinesoroftheirinteractionwithinflammatorymoleculesonleukocytemigrationandfunctions.Inthepast10yr,severalstudiesrevealedtheexistenceofadditionalfeaturesofchemokines:theycanantagonizechemokinereceptorsorsynergizewithotherchemokines,alsobyformingheterocomplexes.Moreover,recentdatashowthatnotonlychemokinesbutalsothealarminhigh‐mobilitygroupbox1canforacomplexwithCXCL12,enhancingitspotencyonCXCR4.Themolecularmechanismunderlyingtheeffectoftheheterocomplexhasbeenpartiallyelucidated,whereasitsstructureisamatterofcurrentinvestigations.ThepresentreviewdiscussesthecurrentknowledgeandrelevanceofthefunctionsofheterocomplexesformedbetweenchemokinesorbetweenthechemokineCXCL12andthealarminhigh‐mobilitygroupbox1.Thesestudieshighlighttheimportanceoftakingintoaccount,whenapproachinginnovativetherapiestargetingthechemokinesystem,alsothefactthatsomechemokinesandmoleculesreleasedininflammation,canconsiderablyaffecttheactivityofchemokinereceptoragonists...

【 授权许可】

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