| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Intracellular immunity: finding the enemy within—how cells recognize and respond to intracellular pathogens | |
| 关键词: PAMP; DAMP; pathogen sensing; | |
| DOI : 10.1189/jlb.4RI0214-090R | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
Historically,onceacellbecameinfected,itwasconsideredtobebeyondallhelp.Bythisstage,theinvadingpathogenhadbreachedtheinnatedefensesandwasbeyondthereachofthehumoralarmoftheadaptiveimmuneresponse.Thepathogencouldstillberemovedbycell‐mediatedimmunity(e.g.,byNKcellsorcytotoxicTlymphocytes),butthesemechanismsnecessitatedthedestructionoftheinfectedcell.However,inrecentyears,ithasbecomeincreasinglyclearthatmanycellspossesssensorandeffectormechanismsfordealingwithintracellularpathogens.Mostofthesemechanismsarenotrestrictedtoprofessionalimmunecellsnordotheyallnecessitatethedestructionofthehost.Inthisreview,weexaminethestrategiesthatcellsusetodetectanddestroypathogensoncethecellmembranehasbeenpenetrated...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904044703131ZK.pdf | 357KB |  download |
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