Senescent profile of angiogenic T cells from systemic lupus erythematosus patients

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: Tang cells;    CD4+CD28null;    cardiovascular disease;    BLyS;    IFN‐;    α;   

DOI  :  10.1189/jlb.5HI0215-042R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Thechronicinflammatoryenvironmentassociatedwithsystemiclupuserythematosuscanleadtoanacceleratedimmunosenescenceresponsiblefortheendothelialdamageandincreasedcardiovascularriskobservedinthesepatients.Thepresentstudyanalyzedtwopopulationswithoppositeeffectsonvascularendothelium,angiogenicTcellsandthesenescentCD4+CD28nullsubset,in84systemiclupuserythematosuspatientsand46healthycontrols.Also,48rheumatoidarthritispatientsand72individualswithtraditionalcardiovascularriskfactorsparticipatedasdiseasecontrols.PhenotypiccharacterizationofCD28+andCD28nullcellswasperformedbyanalyzingmarkersofsenescence(CCR7,CD27,CD57)andcytotoxicity(CD56,perforin,granzymeB,IFN‐γ).IL‐1β,IL‐6,IL‐8,IL‐10,IL‐12,IL‐17A,IFN‐α,IFN‐γ,TNF‐α,Blymphocytestimulator,andGM‐CSFserumlevelswereanalyzedinsystemiclupuserythematosuspatientsandhealthycontrols.CD4+CD28nullcellswerenotablyincreasedinthesystemiclupuserythematosuspatientsanddiseasecontrolscomparedwithhealthycontrols.Incontrast,angiogenicTcellswereonlyreducedinthediseasecontrols(thosewithrheumatoidarthritisortraditionalcardiovascularriskfactors).Nevertheless,ananomalouspresenceofCD28null‐angiogenicTcells,withcytotoxicandsenescentcharacteristics,wasnotedinsystemiclupuserythematosuspatientsinassociationwithanti‐dsDNAtiter,anti‐SSA/RoantibodiesandcirculatingTNF‐α,IL‐8,IFN‐α,andBlymphocytestimulatoramounts.Thissubsetwasalsodetectedinthosewithtraditionalcardiovascularriskfactorsbutnotintherheumatoidarthritispatients.Incontrast,CD28+‐angiogenicTcellswerereducedinthesystemiclupuserythematosuspatientswithcardiovasculardisorders.Inconclusion,CD28expressionmustbeusedtoredefinetheangiogenicTcellpopulation,becauseinpathologicconditions,asenescentCD28null‐angiogenicTcellsubsetwithinflammatory,ratherthanprotective,effectscouldbepresent...

【 授权许可】

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