Serum selenium levels do not differ in type 2 diabetic subjects with and without coronary artery disease

BMC Research Notes

Sotirios Athanaselis¹  Chara A Spiliopoulou¹  Ourania Apostolou²  Athanasia Kokkinari¹  Aggelos Ioannidis¹  Athanasia K Papazafiropoulou²  Stavroula A Papadodima²  Alexios Sotiropoulos² 

[1] Department of Forensic Medicine and Toxicology, National and Kapodistrian University of Athens, Greece;3rd Department of Internal Medicine and Center of Diabetes, General Hospital of Nikaia "Ag. Panteleimon" - Piraeus, Greece

关键词: cardiovascular disease;    type 2 diabetes;    selenium;   

Others  :  1167336
DOI  :  10.1186/1756-0500-4-270

 received in 2011-03-17, accepted in 2011-07-29,  发布年份 2011

【 摘 要 】

Background

The aim of the present study was to investigate whether selenium levels differ between type 2 diabetic subjects with and without coronary artery disease (CAD).

Methods

A total of 200 subjects with type 2 diabetes (100 with CAD and 100 without CAD), consecutively selected from the diabetes outpatient clinic of our hospital were enrolled into the study. A detailed medical history and a physical examination were obtained by all the participants.

Results

Serum selenium levels did not differ between diabetic subjects with and without CAD (102.40 ± 31.10 vs. 108.86 ± 33.88 microg/L, p = 0.16). In diabetic subjects with CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and sex (beta = 0.21, p = 0.03) and glucose levels (beta = 0.25, p = 0.008). In diabetic subjects without CAD multivariate linear regression analysis demonstrated significant independent associations between selenium and peripheral artery disease (beta = 0.16, p = 0.05) and glucose levels (beta = -0.09, p = 0.05).

Conclusion

Serum selenium levels did not differ between diabetic subjects with and without CAD. In diabetic subjects with CAD, the only determinants of serum selenium levels were sex and glucose levels. In diabetic subjects without CAD the only determinants of serum selenium levels were peripheral artery disease and glucose levels.

【 授权许可】

   
2011 Papazafiropoulou et al; licensee BioMed Central Ltd.

【 参考文献 】

• [1]Burk RF: Selenium, an antioxidant nutrient. Nutr Clin Care 2002, 5:75-79.
• [2]Rayman MP: The importance of selenium to human health. Lancet 2000, 356:233-241.
• [3]Thomson CD: Assessment of requirements for selenium and adequacy of selenium status: a review. Eur J Clin Nutr 2004, 58:391-402.
• [4]Salvini S, Hennekens CH, Morris JS, Willett WC, Stampfer MJ: Plasma levels of the antioxidant selenium and risk of myocardial infarction among U.S. physicians. Am J Cardiol 1995, 76:1218-1221.
• [5]Wei WQ, Abnet CC, Qiao YL, Dawsey SM, Dong ZW, Sun XD, Fan JH, Gunter EW, Taylor PR, Mark SD: Prospective study of serum selenium concentrations and esophageal and gastric cardia cancer, heart disease, stroke, and total death. Am J Clin Nutr 2004, 79:80-85.
• [6]Kilander L, Berglund L, Boberg M, Vessby B, Lithell H: Education, lifestyle factors and mortality from cardiovascular disease and cancer. A 25-year follow-up of Swedish 50-year-old men. Int J Epidemiol 2001, 30:1119-1126.
• [7]Laclaustra M, Navas-Acien A, Stranges S, Ordovas JM, Guallar E: Serum selenium concentrations and hypertension in the US Population. Circ Cardiovasc Qual Outcomes 2009, 2:369-376.
• [8]Kornhauser C, Garcia-Ramirez JR, Wrobel K, Pérez-Luque EL, Garay-Sevilla ME, Wrobel K: Serum selenium and glutathione peroxidase concentrations in type 2 diabetes mellitus patients. Primary Care Diabetes 2008, 2:81-85.
• [9]Ruíz C, Alegría A, Barberá R, Farré R, Lagarda J: Selenium, zinc and copper in plasma of patients with type 1 diabetes mellitus in different metabolic control states. J Trace Elem Med Biol 1998, 12:91-95.
• [10]Campbell SC, Aldibbiat A, Marriott CE, Landy C, Ali T, Ferris WF, Butler CS, Shaw JA, Macfarlane WM: Selenium stimulates pancreatic beta-cell gene expression and enhances islet function. FEBS Lett 2008, 582:2333-2337.
• [11]Bleys J, Navas-Acien A, Guallar E: Serum selenium and diabetes in U.S. adults. Diabetes Care 2007, 30:829-834.
• [12]Marcason W: What is the latest research on the connection between selenium and diabetes? J Am Diet Assoc 2008, 108:188.
• [13]Stranges S, Marshall JR, Natarajan R, Donahue RP, Trevisan M, Combs GF, Cappuccio FP, Ceriello A, Reid ME: Effects of long-term selenium supplementation on the incidence of type 2 diabetes: A randomized trial. Ann Intern Med 2007, 147:217-223.
• [14]Stranges S, Sieri S, Vinceti M, Grioni S, Guallar E, Laclaustra M, Muti P, Berrino F, Krogh V: A prospective study of dietary selenium intake and risk of type 2 diabetes. BMC Public Health 2010, 10:564. BioMed Central Full Text
• [15]Chobanian AV, Bakris GL, Black HR, et al.: Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. National Heart, Lung, and Blood Institute; National High Blood Pressure Education Program Coordinating Committee. Seventh report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure. Hypertension 2003, 42:1206-1252.
• [16]Sieri S, Pala V, Brighenti F, Pellegrini N, Muti P, Micheli A, Evangelista A, Grioni S, Contiero P, Berrino F, Krogh V: Dietary glycemic index, glycemic load, and the risk of breast cancer in an Italian prospective cohort study. Am J Clin Nutr 2007, 86:1160-6.
• [17]Salvini S, Parpinel M, Gnagnarella P, Maisonneuve P, Turrini A: Italian food composition database for epidemiologic studies. Milan, Italy: European Institute of Oncology 1998.
• [18]Friedewald WT, Levy RI, Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preperative ultracentrifuge. Clin Chem 1972, 18:499-502.
• [19]Report of the Expert Committee on the Diagnosis and Classification of Diabetes Mellitus Diabetes Care 1997, 20:1183-1197.
• [20]Hughes K, Choo M, Kuperan P, Ong CN, Aw TC: Cardiovascular risk factors in non-insulin-dependent diabetics compared to non-diabetic controls: a population-based survey among Asians in Singapore. Atherosclerosis 1998, 136:25-31.
• [21]Navarro-Alarcón M, López-G de la Serrana H, Pérez-Valero V, López-Martínez C: Serum and urine selenium concentrations as indicators of body status in patients with diabetes mellitus. Sci Total Environ 1999, 228:79-85.
• [22]Laclaustra M, Navas-Acien A, Stranges S, Ordovas JM, Guallar E: Serum selenium concentrations and diabetes in U.S. adults: National Health and Nutrition Examination Survey (NHANES) 2003-2004. Environ Health Perspect 2009, 117:1409-1413.
• [23]Czernichow S, Couthouis A, Bertrais S, Vergnaud AC, Dauchet L, Galan P, Hercberg S: Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations. Am J Clin Nutr 2006, 84:395-399.
• [24]Rajpathak S, Rimm E, Morris JS, Hu F: Toenail selenium and cardiovascular disease in men with diabetes. J Am Coll Nutr 2005, 24:250-256.
• [25]Gebre-Medhin M, Ewald U, Plantin LO, Tuvemo T: Elevated serum selenium in diabetic children. Acta Paediatr Scand 1984, 73:109-114.
• [26]Kilinc M, Guven MA, Ezer M, Ertas IE, Coskun A: Evaluation of serum selenium levels in Turkish women with gestational diabetes mellitus, glucose intolerants, and normal controls. Biol Trace Elem Res 2008, 123:35-40.
• [27]Yoshizawa K, Ascherio A, Morris JS, Stampfer MJ, Giovannucci E, Baskett CK, Willett WC, Rimm EB: Prospective study of selenium levels in toenails and risk of coronary heart disease in men. Am J Epidemiol 2003, 158:852-860.
• [28]Hu FB, Leitzmann MF, Stampfer MJ, Colditz GA, Willett WC, Rimm EB: Physical activity and television watching in relation to risk for type 2 diabetes mellitus in men. Arch Intern Med 2001, 161:1542-1548.
• [29]Stranges S, Galletti F, Farinaro E, D'Elia L, Russo O, Iacone R, Capasso C, Carginale V, De Luca V, Della Valle E, Cappuccio FP, Strazzullo P: Associations of selenium status with cardiometabolic risk factors: An 8-year follow-up analysis of the Olivetti Heart Study. Atherosclerosis 2011, in press.