Possible Mechanisms of Local Tissue Renin-Angiotensin System Activation in the Cardiorenal Metabolic Syndrome and Type 2 Diabetes Mellitus

Cardiorenal medicine

Melvin R. Hayden ; Kurt M. Sowers ; Lakshmi Pulakat ; Tejaswini Joginpally ; Bennett Krueger ; Adam Whaley-Connell ; James R. Sowers

关键词: Adipose tissue;    Insulin resistance;    Mast cells;    Reactive oxygen species;    Redox stress;    Renin-angiotensin system;    Type 2 diabetes mellitus;   

DOI  :  10.1159/000329926

学科分类：心脏病和心血管学

来源: S Karger AG

【 摘 要 】

Abstract The role of local tissue renin-angiotensin system (tRAS) activation in the cardiorenal metabolic syndrome (CRS) and type 2 diabetes mellitus (T2DM) is not well understood. To this point, we posit that early redox stress-mediated injury to tissues and organs via accumulation of excessive reactive oxygen species (ROS) and associated wound healing responses might serve as a paradigm to better understand how tRAS is involved. There are at least five common categories responsible for generat.

【 授权许可】

CC BY