HVEM/LIGHT/BTLA/CD160 cosignaling pathways as targets for immune regulation

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: coinhibition;    costimulation;    transplantation;    autoimmunity;   

DOI  :  10.1189/jlb.0809590

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Immunosuppressioniscurrentlythetreatmentofchoicetoattenuatethechronicdeteriorationoftissuefunctionasaresultoftheeffectormechanismsoftheimmunologicalresponseintransplantrejectionandautoimmunediseases.However,globalimmunosuppressiongreatlyincreasestheriskofacquiringlife‐threateninginfectionsandisassociatedwithorgantoxicitywhenusedlong‐term.Thus,alternativeapproachesthatinhibitonlytheunwantedimmuneresponsesandpreservegeneralimmunityarehighlydesirable.Thereceptor/ligandpairsinvolvedinthecross‐talkbetweenDCandTcellshavebeenthefocusofintenseandexcitingresearchduringthelastdecade.TheHVEM/LIGHT/BTLA/CD160costimulatory/coinhibitorypathwayhasemergedasapotentialtargetforthedevelopmentofimmunetherapeuticinterventions.Herein,wewillsummarizeanddiscusshowblockadeofthecostimulatoryHVEM/LIGHTinteractionoragonistsignalingthroughtheinhibitoryBTLAandCD160receptorscouldcontributetothecontrolofdeleteriousimmuneresponses...

【 授权许可】

CC BY