Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
CD4+/CD8+ double‐positive T cells: more than just a developmental stage? | |
关键词: immune regulation; cytotoxic potential; T cell plasticity; | |
DOI : 10.1189/jlb.1RU0814-382 | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
CD4+/CD8+DPthymocytesareawell‐describedTcelldevelopmentalstagewithinthethymus.However,oncedifferentiated,theCD4+lineageortheCD8+lineageisgenerallyconsideredtobefixed.Nevertheless,matureCD4+/CD8+DPTcellshavebeendescribedinthebloodandperipherallymphoidtissuesofnumerousspecies,aswellasinnumerousdiseasesettings,includingcancer.TheexpressionofCD4andCD8isregulatedbyaverystricttranscriptionalprograminvolvingthetranscriptionfactorsRunx3andThPOK.InitiallythoughttobemutuallyexclusivewithinCD4+andCD8+Tcells,CD4+/CD8+Tcellpopulations,outsideofthethymus,haverecentlybeendescribedtoexpressconcurrentlyThPOKandRunx3.ConsiderableheterogeneityexistswithintheCD4+/CD8+DPTcellpool,andthefunctionofCD4+/CD8+Tcellpopulationsremainscontroversial,withconflictingreportsdescribingcytotoxicorsuppressiverolesforthesecells.Inthisreview,wedescribehowtranscriptionalregulation,lineageoforigin,heterogeneityofCD4andCD8expression,age,species,andspecificdiseasesettingsinfluencethefunctionalityofthisrarelystudiedTcellpopulation...
【 授权许可】
CC BY
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO201904043494639ZK.pdf | 672KB | download |