Leprosy as a model to understand cancer immunosurveillance and T cell anergy

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: Immunoediting;    T cell plasticity;    exhaustion;   

DOI  :  10.1189/jlb.5RU1215-537RR

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

LeprosyisadiseasecausedbyMycobacteriumlepraethatpresentsonaspectrumofbothclinicalmanifestationsandTcellresponse.Ononeendofthisspectrum,tuberculoidleprosyisawell‐controlleddisease,characterizedbyacell‐mediatedimmunityandimmunosurveillance.Ontheoppositeendofthespectrum,lepromatousleprosyischaracterizedbyM.lepraeproliferationandTcellanergy.Similartoprogressivetumorcells,M.lepraeescapesimmunosurveillanceinmoresevereformsofleprosy.ThemechanismsbywhichM.lepraeisabletoevadethehostimmuneresponseinvolvemany,includingthealterationsoflipiddroplets,microRNA,andSchwanncells,andinvolvetheregulationofimmuneregulators,suchasthenegativecheckpointregulatorsCTLA‐4,programmeddeath1,andV‐domainIgsuppressorofTcellactivation—importanttargetsintoday'scancerimmunotherapies.Themeansbywhichtumorcellsbecomeabletoescapeimmunosurveillancethroughnegativecheckpointregulatorsareevidencedbythesuccessesoftreatments,suchasnivolumabandipilimumab.Manyparallelscanbedrawnbetweentheimmuneresponsesseeninleprosyandcancer.Therefore,theunderstandingofhowM.lepraeencouragesimmuneescapeduringproliferativediseasestateshaspotentialtoaddtoourunderstandingofcancerimmunotherapy...

【 授权许可】

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