Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
Leprosy as a model to understand cancer immunosurveillance and T cell anergy | |
关键词: Immunoediting; T cell plasticity; exhaustion; | |
DOI : 10.1189/jlb.5RU1215-537RR | |
学科分类:生理学 | |
来源: Federation of American Societies for Experimental Biology | |
【 摘 要 】
LeprosyisadiseasecausedbyMycobacteriumlepraethatpresentsonaspectrumofbothclinicalmanifestationsandTcellresponse.Ononeendofthisspectrum,tuberculoidleprosyisawell‐controlleddisease,characterizedbyacell‐mediatedimmunityandimmunosurveillance.Ontheoppositeendofthespectrum,lepromatousleprosyischaracterizedbyM.lepraeproliferationandTcellanergy.Similartoprogressivetumorcells,M.lepraeescapesimmunosurveillanceinmoresevereformsofleprosy.ThemechanismsbywhichM.lepraeisabletoevadethehostimmuneresponseinvolvemany,includingthealterationsoflipiddroplets,microRNA,andSchwanncells,andinvolvetheregulationofimmuneregulators,suchasthenegativecheckpointregulatorsCTLA‐4,programmeddeath1,andV‐domainIgsuppressorofTcellactivation—importanttargetsintoday'scancerimmunotherapies.Themeansbywhichtumorcellsbecomeabletoescapeimmunosurveillancethroughnegativecheckpointregulatorsareevidencedbythesuccessesoftreatments,suchasnivolumabandipilimumab.Manyparallelscanbedrawnbetweentheimmuneresponsesseeninleprosyandcancer.Therefore,theunderstandingofhowM.lepraeencouragesimmuneescapeduringproliferativediseasestateshaspotentialtoaddtoourunderstandingofcancerimmunotherapy...
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