| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Histamine regulates autoreactive T cell activation and adhesiveness in inflamed brain microcirculation | |
| 关键词: autoimmunity; EAE; MS; cytokine; chemokine; | |
| DOI : 10.1189/jlb.0910486 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
HistaminemaycontributetothepathologyofMSanditsanimalmodelEAE.WeexploredtheeffectsofhistamineandspecificHRagonistsonactivationandmigratorycapacityofmyelin‐autoreactiveTcells.WeshowthathistamineinvitroinhibitsproliferationandIFN‐γproductionofmouseTcellsactivatedagainstPLP139–151.TheseeffectsweremimickedbytheH1RagonistHTMTandtheH2RagonistdimapritandwereassociatedwithreducedactivationofERK½kinaseandwithincreasedlevelsofcellcycleinhibitorp27Kip‐1,bothinvolvedinTcellproliferationandanergy.H1RandH2Ragonistsreducedspontaneousandchemokine‐inducedadhesionofautoreactiveTcellstoICAM‐1invitroandblockedfirmadhesionofthesecellsininflamedbrainmicrocirculationinvivo.Thushistamine,throughH1RandH2R,inhibitsactivationofmyelin‐autoreactiveTcellsandtheirabilitytotrafficthroughtheinflamedBBB.StrategiesaimedatinterferingwiththehistamineaxismighthaverelevanceinthetherapyofautoimmunediseaseoftheCNS...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904043463447ZK.pdf | 1468KB |  download |
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