| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| HIV‐1 envelope–receptor interactions required for macrophage infection and implications for current HIV‐1 cure strategies | |
| 关键词: CD4; CCR5; CXCR4; reservoir; | |
| DOI : 10.1189/jlb.0713368 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
MyeloidcellsresidingintheCNSandlymphoidtissuesaretargetsforproductiveHIV‐1replication,andtheirinfectioncontributestothepathologicalmanifestationsofHIV‐1infection.TheEnvscanadoptalteredconfigurationstoovercomeentryrestrictionsinmacrophagesviaamoreefficientand/oralteredmechanismofengagementwithcellularreceptors.ThisreviewhighlightsevidencesupportinganimportantroleformacrophagesinHIV‐1pathogenesisandpersistence,whichneedtobeconsideredforstrategiesaimedatachievingafunctionalorsterilizingcure.WealsohighlightthatthemolecularmechanismsunderlyingHIV‐1tropismformacrophagesarecomplex,involvingenhancedand/oralteredinteractionswithCD4,CCR5,and/orCXCR4,andthatthenatureoftheseinteractionsmaydependontheanatomicallocationofthevirus...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904043341957ZK.pdf | 730KB |  download |
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