Thirty years on: HIV receptor gymnastics and the prevention of infection

BMC Biology

Opinion

Robin A Weiss¹ 

[1] Wohl Virion Centre, Division of Infection & Immunity, University College London, Gower Street, WC1E, London, UK;

关键词: AIDS;    HIV;    cell receptors;    CD4;    CCR5;    CXCR4;    Therapy;   

DOI  :  10.1186/1741-7007-11-57

 received in 2013-04-10, accepted in 2013-05-10,  发布年份 2013

来源: Springer

【 摘 要 】

During 30 years of research on human immunodeficiency virus (HIV), our knowledge of its cellular receptors - CD4, CCR5 and CXCR4 - has illuminated aspects of the pathogenesis of the acquired immune deficiency syndrome (AIDS). Studying how the HIV envelope glycoproteins interact with the receptors led to anti-retroviral drugs based on blocking the docking or fusion of virus to the host cell. Genetic polymorphisms of CCR5 determine resistance to HIV infection and the rate of progression to AIDS. Eliciting neutralizing antibodies to the sites of receptor interaction on HIV glycoproteins is a promising approach to HIV vaccine development.

【 授权许可】

CC BY   
© Weiss; licensee BioMed Central Ltd. 2013