RelB: an outlier in leukocyte biology

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: NF‐;    κ;    B;    inflammation;    endotoxin tolerance;    bioenergy;   

DOI  :  10.1189/jlb.0513305

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

RelBisoneofthemoreunusualmembersoftheNF‐κBfamily.Thisfamily,arguablythebestknowngroupoftranscriptionregulators,regulatesanastonishingarrayofcelltypesandbiologicalprocesses.Thisincludesregulationofcellgrowth,differentiationanddeathbyapoptosis,andthedevelopmentandfunctionoftheinnateandadaptive‐immunesystem.RelBisbestknownforitsrolesinlymphoiddevelopment,DCbiology,andnoncanonicalsignaling.Withinthelastfewyears,however,surprisingfunctionsofRelBhaveemerged.TheN‐terminalleucinezippermotifofRelB,amotifuniqueamongtheNF‐κBfamily,mayassociatewithmorediverseDNAsequencesthanotherNF‐κBmembers.RelBiscapableofdirectbindingtotheAhRthatsupportsthexenobiotic‐detoxifyingpathway.RelBcanregulatethecircadianrhythmbydirectlybindingtotheBMALpartnerofCLOCK.Finally,RelBalsocoupleswithbioenergyNAD+sensorSIRT1tointegrateacuteinflammationwithchangesinmetabolismandmitochondrialbioenergetics.Inthisreview,wewillexploretheseuniqueaspectsofRelB,specificallywithregardtoitsroleinimmunity...

【 授权许可】

CC BY