| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Dendritic cells transmit HIV‐1 through human small intestinal mucosa | |
| 关键词: epithelium; trans‐; infection; lamina propria; | |
| DOI : 10.1189/jlb.0909605 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
TodissecttheearlyeventsinthetransmissionofHIV‐1frommothertochild,weinvestigatedwhetherDCsparticipateinHIV‐1entryintohumansmallintestinalmucosa.WeisolatedhumanMNLsfromjejunallaminapropriaandidentifiedasubpopulationofCD11c+HLA‐DR+MNLsthatexpressedDC‐SIGN,CD83,CD86,CD206,andCCR7,indicatingaDCphenotype.JejunalDCsalsoexpressedtheHIV‐1receptorCD4andcoreceptorsCCR5andCXCR4andinsuspensionrapidlytookupcell‐freeHIV‐1.HIV‐1inoculatedontotheapicalsurfaceofexplantedjejunumwastransportedbylaminapropriaDCsthroughthemucosaandtransmittedintranstobloodandintestinallymphocytes.Thesefindingsindicatethatinadditiontointestinalepithelialcells,whichweshowedpreviouslytranscytoseinfectiousHIV‐1toindicatorcells,intestinalDCsplayanimportantroleintransportingHIV‐1throughtheintestinalmucosaandthesubsequenttransmissiontoTcells...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
|---|---|---|---|
| RO201904042143807ZK.pdf | 591KB |  download |
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