Differential regulation of MHC II and invariant chain expression during maturation of monocyte‐derived dendritic cells

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: CD74;    Ii translation/transport/half life/degradation;    DC maturation;   

DOI  :  10.1189/jlb.0311150

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

DCsarepotentinitiatorsofadaptiveimmuneresponsestowardinvadingpathogens.Uponreceptionofpathogenicstimuli,DCsinitiateacomplexdifferentiationprogram,culminatinginmatureDCswithanextremecapacitytoactivatenaïveTcells.Duringthismaturation,DCsreducethesynthesisandturnoverofMHCIImolecules.ThisallowsforastablepopulationofMHCII,presentingpeptidescapturedatthetimeandplaceofactivation,thusprovokingspecificimmuneresponsestowardtheactivatingpathogen.TheefficientloadingofantigenicpeptidesontoMHCIIisvitallydependentontheaccessorymoleculeIi,whichaidsintheassemblyoftheMHCIIα‐andβ‐chainsintheERanddirectstheirtraffickingtotheendocyticcompartments,wheretheyencounterendocytosedantigen.However,IiplaysadditionalrolesinDCfunctionbyinfluencingmigration,antigenuptake,andprocessing.ToexaminethebiosyntheticbackgroundfordiverseIifunctionsinDCs,weinvestigatedmRNAandproteinlevelsofIicomparedwithMHCIIinhumanmoDCsduringmaturationusingvariousstimuli.WefindthattheproductionofIididnotcorrelatewiththatofMHCIIandthatmatureDCsmaintainabundantlevelsofIidespiteareducedproductionofnewMHCII...

【 授权许可】

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