| Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society | |
| Differential regulation of MHC II and invariant chain expression during maturation of monocyte‐derived dendritic cells | |
| 关键词: CD74; Ii translation/transport/half life/degradation; DC maturation; | |
| DOI : 10.1189/jlb.0311150 | |
| 学科分类：生理学 | |
| 来源: Federation of American Societies for Experimental Biology | |
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【 摘 要 】
DCsarepotentinitiatorsofadaptiveimmuneresponsestowardinvadingpathogens.Uponreceptionofpathogenicstimuli,DCsinitiateacomplexdifferentiationprogram,culminatinginmatureDCswithanextremecapacitytoactivatenaïveTcells.Duringthismaturation,DCsreducethesynthesisandturnoverofMHCIImolecules.ThisallowsforastablepopulationofMHCII,presentingpeptidescapturedatthetimeandplaceofactivation,thusprovokingspecificimmuneresponsestowardtheactivatingpathogen.TheefficientloadingofantigenicpeptidesontoMHCIIisvitallydependentontheaccessorymoleculeIi,whichaidsintheassemblyoftheMHCIIα‐andβ‐chainsintheERanddirectstheirtraffickingtotheendocyticcompartments,wheretheyencounterendocytosedantigen.However,IiplaysadditionalrolesinDCfunctionbyinfluencingmigration,antigenuptake,andprocessing.ToexaminethebiosyntheticbackgroundfordiverseIifunctionsinDCs,weinvestigatedmRNAandproteinlevelsofIicomparedwithMHCIIinhumanmoDCsduringmaturationusingvariousstimuli.WefindthattheproductionofIididnotcorrelatewiththatofMHCIIandthatmatureDCsmaintainabundantlevelsofIidespiteareducedproductionofnewMHCII...
【 授权许可】
CC BY
【 预 览 】
| Files | Size | Format | View |
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| RO201901235693051ZK.pdf | 2297KB |  download |
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