Immune deficiency vs. immune excess in inflammatory bowel diseases—STAT3 as a rheo‐STAT of intestinal homeostasis

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: mucosal immunology;    GWAS;    cytokines;    IL‐;    22;   

DOI  :  10.1189/jlb.5MR0515-221R

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

Genome‐wideassociationstudieshaveprovidedmanygeneticalterations,conferringsusceptibilitytomultifactorialpolygenicdiseases,suchasinflammatoryboweldiseases.Yet,howspecificgeneticalterationsfunctionallyaffectintestinalinflammationoftenremainselusive.Itisnoteworthythatalargeoverlapofgenesinvolvedinimmunedeficiencieswiththoseconferringinflammatoryboweldiseaseriskhasbeennoted.Thishasprovidednewargumentsforthedebateonwhetherinflammatoryboweldiseasearisesfromeitheranexcessoradeficiencyintheimmunesystem.Inthisreview,wehighlightthefunctionaleffectofaninflammatoryboweldisease‐riskallele,whichcannotbededucedfromgenome‐wideassociationstudiesdataalone.Asexemplifiedbythetranscriptionfactorsignaltransducerandactivatoroftranscription3(STAT3),weshowthatasinglegenecanhaveaplethoraofeffectsinvariouscelltypesofthegut.Theseeffectsmayindividuallycontributetotherestorationofintestinalhomeostasisontheonehandorpavethewayforexcessiveimmunopathologyontheother,asaninflammatory“rheo‐STAT”...

【 授权许可】

CC BY