Regulatory B cells suppress imiquimod‐induced, psoriasis‐like skin inflammation

Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society

关键词: cytokines;    B10 cells;    IL‐;    10;   

DOI  :  10.1189/jlb.1112562

学科分类：生理学

来源: Federation of American Societies for Experimental Biology

【 摘 要 】

PsoriasisisaninflammatorycutaneousdisordercharacterizedbymarkedepidermalthickeningandTh1andTh17cellinfiltration.Atpresent,thecontributionofBcellstothepathogenesisofpsoriasisisunclear.Inmice,topicalapplicationofimiquimodinducesinflamedskinlesionsandservesasanexperimentalanimalmodelforhumanpsoriasis.Inthisstudy,weshowedthatimiquimod‐inducedskininflammationwasmoresevereinCD19−/−thanWTmice.TheseinflammatoryresponseswerenegativelyregulatedbyauniqueIL‐10‐producingCD1dhiCD5+regulatoryBcellsubset(B10cells)thatwasabsentinCD19−/−miceandrepresentedonly1–2%ofsplenicB220+cellsinWTmice.SplenicB10cellsenteredthecirculationandmigratedtodrainingLNsduringimiquimod‐inducedskininflammation,therebysuppressingIFN‐γandIL‐17production.Furthermore,adoptivetransferoftheseB10cellsfromWTmicereducedinflammationinCD19−/−mice.ThepresentfindingsprovidedirectevidencethatB10cellsregulateimiquimod‐inducedskininflammationandofferinsightsintoregulatoryBcell‐basedtherapiesforthetreatmentofpsoriasis...

【 授权许可】

CC BY